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Publikation: Zeitschriftenartikel
Xenogeneic and stem cell-based therapy for cardiovascular diseases
Grunddaten
Abstract
Autoren
Einrichtung
Grunddaten
Titel
Xenogeneic and stem cell-based therapy for cardiovascular diseases
Untertitel
genetic engineering of porcine cells and their applications in heart regeneration
Erscheinungsjahr
2020
Seiten (von – bis)
1 – 22
Band
21
Heft-Nr.
24
Jahr
2020
Publikationsform
Elektronische Ressource
Publikationsart
Zeitschriftenartikel
Sprache
Englisch
DOI
10.3390/ijms21249686
Letzte Änderung
03.11.2021 06:04:05
Bearbeitungsstatus
durch UB Rostock abschließend validiert
Dauerhafte URL
http://purl.uni-rostock.de/fodb/pub/66333
Links zu Katalogen
Abstract
Cardiovascular diseases represent a major health concern worldwide with few therapy options for ischemic injuries due to the limited regeneration potential of affected cardiomyocytes. Innovative cell replacement approaches could facilitate efficient regenerative therapy. However, despite extensive attempts to expand primary human cells in vitro, present technological limitations and the lack of human donors have so far prevented their broad clinical use. Cell xenotransplantation might provide an ethically acceptable unlimited source for cell replacement therapies and bridge the gap between waiting recipients and available donors. Pigs are considered the most suitable candidates as a source for xenogeneic cells and tissues due to their anatomical and physiological similarities with humans. The potential of porcine cells in the field of stem cell-based therapy and regenerative medicine is under intensive investigation. This review outlines the current progress and highlights the most promising approaches in xenogeneic cell therapy with a focus on the cardiovascular system. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Autoren
Galow, Anne-Marie
Goldammer, Tom
Höflich, Andreas
Einrichtung
AUF/Molekularbiologie und Genetik der Fische (ThürM)