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Qualitative effect of tissue heterogeneity and modiolus porosity on the transmembrane potential of type-1 spiral ganglion neurons in the human cochlea ( Dissertationsschrift )

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Electric stimulation of auditory nerve by cochlear implants has been a successful clinical intervention to treat the sensorineural deafness. However, various micro-anatomical factors have not been considered in the state of the art models while studying the interaction between the applied electric field and the auditory nerve. The present finite element modeling study suggests that the modiolus porosity and tissue heterogeneity significantly alter the electric field distribution in the Rosenthals canal and thereby affect the cochlear implant functionality.<eng>

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