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Assessing the impact of sodium butyrate and a light-activated proton pump on energy metabolism and lifespan of Drosophila melanogaster and Caenorhabditis elegans ( Dissertationsschrift )

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In this thesis, the impact of sodium butyrate (SB) on mitochondrial and metabolic function and lifespan was investigated. SB treatment showed a rapid and transient increase in oxygen consumption in fly heads. Mass spectrometry analysis revealed incorporation of labeled SB into mitochondrial pathway metabolites. An SB-independent way for mitochondrial activation was assessed in this work. The mitochondrial membrane potential of C. elegans was increased, using a light-activated proton pump, resulting in an extended median lifespan, even if the intervention took part in mid- or late-staged worms.<eng>

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