Publikation: Zeitschriftenartikel

Analyzing longitudinal wb-MRI data and clinical course in a cohort of former smoldering multiple myeloma patients

Grunddaten
Abstract
Autoren
Einrichtung

Grunddaten

Titel	Analyzing longitudinal wb-MRI data and clinical course in a cohort of former smoldering multiple myeloma patients
Untertitel	connections between MRI findings and clinical progression patterns
Erscheinungsjahr	2021
Seiten (von – bis)	1 – 16
Band	13
Heft-Nr.	5
Jahr	2021
Publikationsform	Elektronische Ressource
Publikationsart	Zeitschriftenartikel
Sprache	Englisch
DOI	10.3390/cancers13050961
Letzte Änderung	09.02.2022 13:02:02
Bearbeitungsstatus	durch UB Rostock abschließend validiert
Dauerhafte URL	http://purl.uni-rostock.de/fodb/pub/67327
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Abstract

The purpose of this study was to analyze size and growth dynamics of focal lesions (FL) as well as to quantify diffuse infiltration (DI) in untreated smoldering multiple myeloma (SMM) patients and correlate those MRI features with timepoint and cause of progression. We investigated 199 whole-body magnetic resonance imaging (wb-MRI) scans originating from longitudinal imaging of 60 SMM patients and 39 computed tomography (CT) scans for corresponding osteolytic lesions (OL) in 17 patients. All FLs >5 mm were manually segmented to quantify volume and growth dynamics, and DI was scored, rating four compartments separately in T1- and fat-saturated T2-weighted images. The majority of patients with at least two FLs showed substantial spatial heterogeneity in growth dynamics. The volume of the largest FL (p = 0.001, c-index 0.72), the speed of growth of the fastest growing FL (p = 0.003, c-index 0.75), the DI score (DIS, p = 0.014, c-index 0.67), and its dynamic over time (DIS dynamic, p < 0.001, c-index 0.67) all significantly correlated with the time to progression. Size and growth dynamics of FLs correlated significantly with presence/appearance of OL in CT within 2 years after the respective MRI assessment (p = 0.016 and p = 0.022). DIS correlated with decrease of hemoglobin (p < 0.001). In conclusion, size and growth dynamics of FLs correlate with prognosis and local bone destruction. Connections between MRI findings and progression patterns (fast growing FLOL; DIShemoglobin decrease) might enable more precise diagnostic and therapeutic approaches for SMM patients in the future.

Autoren

Wennmann, Markus Sebastian

Hielscher, Thomas

Kintzelé, Laurent

Menze, Bjoern Holger

Langs, Georg

Merz, Maximilian

Sauer, Sandra

Kauczor, Hans-Ulrich

Schlemmer, Heinz-Peter

Delorme, Stefan

Goldschmidt, Hartmut

Weinhold, Niels

Hillengaß, Jens

Weber, Marc-André

Einrichtung

UMR/Institut für Diagnostische und Interventionelle Radiologie, Kinder- und Neuroradiologie