In this study the recognition maps obtained by the simultaneous topography and recognition (TREC) imaging revealed that Fc receptors are distributed in micro-domains of sizes 4nm to 200nm. The fluorescent and electron-microscopy provided further evidence that these clusters are located within close proximity of mannose receptors. This pattern of distribution of FcRs and MRs led to inhibition of the MR mediated mediated phagocytosis. The data presented in this thesis provide evidences of cross-talk between FcR mediated and MR mediated phagocytosis.
