Myocardial infarction is an irreversible injury of the heart muscle leading to complex changes in ventricular construction. Hence, the reduction and repair of myocardial damage are great challenges in clinical research. The objective of the present work was the development of novel biomedical techniques for cardiac regeneration employing targeted gene transfer and biomaterial-based tissue engineering. Using a rat model of MI, the therapeutic effect of stable magnetic field-guided MNBs/AdhVEGF complexes was evaluated on the one hand and intracardiac matrigel injection on the other hand.
