The periodontal pocket is characterized by varying oxygen partial pressures and an omnipresence of various bacterial species. Patients with periodontitis suffer from an opportunistic infection leading to a progressive loss and resulting in the loss of teeth. Application of stem cells could be a promising strategy for the periodontal regeneration. During the infection, PMNs are the first cells to be recruited. The aim of this study was to establish a co-cultivation system consisting of periodontal pathogens, stem cells and PMNs.
