Fetal growth restriction affects pregnancies leading to perinatal mortality and morbidity. Current diagnostic method is by ultrasound inspection but cannot differentiate SGA fetuses from IUGR fetuses. Maternal serum from IUGR, SGA and control pregnant women were analysed using affinity-mass spectrometry. Separation confidence reached a sensitivity of 0.90, specificity of 0.79 with an area under curve of 0.88 in receiver operator characteristics. Proteome profiling by affinity-mass spectrometry during pregnancy provides a reliable method for risk assessment of impaired development in fetuses.<eng>
