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Identification of the microsatellite stability status and inhibitor of NF-kappa-B expression levels as biomarkers to predict sensitivity to pharmaceutical curcumin in colorectal cancer cells ( Dissertationsschrift )

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The present study aimed at 1) testing the sensitivity of CRC cell lines with defined molecular alterations to curcumin; 2) mechanistically analyzing sensitive CRC cell lines in order to identify the mode-of-action; 3) identifying biomarkers associated with curcumin sensitivity; 4) establishing a predictive model using biomarkers to predict the sensitivity of additional CRC cell line to curcumin.<eng>

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