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Publikation: Zeitschriftenartikel
How do parents perceive adverse drug events of their children's anticonvulsant medication?
Grunddaten
Abstract
Autoren
Einrichtung
Grunddaten
Titel
How do parents perceive adverse drug events of their children's anticonvulsant medication?
Erscheinungsjahr
2018
Seiten (von – bis)
427 – 433
Band
22
Heft-Nr.
3
Jahr
2018
Publikationsform
Elektronische Ressource
Publikationsart
Zeitschriftenartikel
Sprache
Englisch
DOI
10.1016/j.ejpn.2018.01.027
Letzte Änderung
10.03.2021 06:10:17
Bearbeitungsstatus
durch UB Rostock abschließend validiert
Dauerhafte URL
http://purl.uni-rostock.de/fodb/pub/65294
Links zu Katalogen
Abstract
Background - The main source of knowledge on adverse drug events (ADE) are physicians' reports in controlled clinical trials. In contrast, little is known about the parents' perception of ADE of anticonvulsants their children receive. - Methods - After approval by the local ethics committee, we performed a survey in a neuropediatric outpatient clinic of a university hospital. Based on a structured questionnaire, we interviewed parents of children with current anticonvulsant treatment regarding (i) their fears about potential ADE, (ii) experienced ADE according to parents, and (iii) implications of ADE on the child's life. - Results - Parents of 150 patients took part in the interview. (i) 95 (63.3%) parents expressed fears concerning ADE, mostly liver injury/liver failure (33 [22%]). (ii) 129 (86%) parents reported experienced ADE, mostly sedation (65 [43.3%]) and abnormal behavior (54 [36%]). (iii) Parents reported substantial implications of ADE on the child's daily life for 84 (56%) children, and 63 (42%) parents expressed a negative impact on the child's development. - Conclusion - We recognized a great discrepancy between those ADE that were feared and those that were experienced. Parents feared life-threatening ADE and experienced less severe ADE that nevertheless have a negative impact on the child's daily life.
Autoren
Bach, Vivien Angela
Syrbe, Steffen
Bertsche, Astrid
Einrichtung
UMR/Klinik und Poliklinik für Psychiatrie, Neurologie, Psychosomatik und Psychotherapie im Kindes- und Jugendalter (KJPP)