Publikation: Zeitschriftenartikel

Xenogeneic and stem cell-based therapy for cardiovascular diseases

Grunddaten
Abstract
Autoren
Einrichtung

Grunddaten

Titel	Xenogeneic and stem cell-based therapy for cardiovascular diseases
Untertitel	genetic engineering of porcine cells and their applications in heart regeneration
Erscheinungsjahr	2020
Seiten (von – bis)	1 – 22
Band	21
Heft-Nr.	24
Jahr	2020
Publikationsform	Elektronische Ressource
Publikationsart	Zeitschriftenartikel
Sprache	Englisch
DOI	10.3390/ijms21249686
Letzte Änderung	03.11.2021 06:04:05
Bearbeitungsstatus	durch UB Rostock abschließend validiert
Dauerhafte URL	http://purl.uni-rostock.de/fodb/pub/66333
Links zu Katalogen

Abstract

Cardiovascular diseases represent a major health concern worldwide with few therapy options for ischemic injuries due to the limited regeneration potential of affected cardiomyocytes. Innovative cell replacement approaches could facilitate efficient regenerative therapy. However, despite extensive attempts to expand primary human cells in vitro, present technological limitations and the lack of human donors have so far prevented their broad clinical use. Cell xenotransplantation might provide an ethically acceptable unlimited source for cell replacement therapies and bridge the gap between waiting recipients and available donors. Pigs are considered the most suitable candidates as a source for xenogeneic cells and tissues due to their anatomical and physiological similarities with humans. The potential of porcine cells in the field of stem cell-based therapy and regenerative medicine is under intensive investigation. This review outlines the current progress and highlights the most promising approaches in xenogeneic cell therapy with a focus on the cardiovascular system. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.

Autoren

Galow, Anne-Marie
Goldammer, Tom
Höflich, Andreas

Einrichtung

AUF/Molekularbiologie und Genetik der Fische (ThürM)