Publikation: Zeitschriftenartikel

Pathological response in the breast and axillary lymph nodes after neoadjuvant systemic treatment in patients with initially node-positive breast cancer correlates with disease free survival

Grunddaten
Abstract
Autoren
Einrichtung

Grunddaten

Titel	Pathological response in the breast and axillary lymph nodes after neoadjuvant systemic treatment in patients with initially node-positive breast cancer correlates with disease free survival
Untertitel	an exploratory analysis of the GeparOcto trial
Erscheinungsjahr	2022
Seiten (von – bis)	1 – 12
Band	14
Heft-Nr.	3
Jahr	2022
Publikationsform	Elektronische Ressource
Publikationsart	Zeitschriftenartikel
Sprache	Englisch
DOI	10.3390/cancers14030521
Letzte Änderung	21.07.2022 06:02:06
Bearbeitungsstatus	durch UB Rostock abschließend validiert
Dauerhafte URL	http://purl.uni-rostock.de/fodb/pub/68374
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Abstract

Background: The conversion of initially histologically confirmed axillary lymph node-positive (pN+) to ypN0 after neoadjuvant systemic treatment (NAST) is an important prognostic factor in breast cancer (BC) patients and may influence surgical de-escalation strategies. We aimed to determine pCR rates in lymph nodes (pCR-LN), the breast (pCR-B), and both (tpCR) in women who present with pN+ BC, to assess predictors for response and the impact of pCR-LN, pCR-B, and tpCR on invasive disease-free survival (iDFS). Methods: Retrospective, exploratory analysis of 242 patients with pN+ at diagnosis from the multicentric, randomized GeparOcto trial. Results: Of 242 patients with initially pN+ disease, 134 (55.4%) had a pCR-LN, and 109 (45.0%) a pCR-B. Of the 109 pCR-B patients, 9 (8.3%) patients had involved LN, and 100 (41.3%) patients had tpCR. Those with involved LN still had a bad prognosis. As expected, pCR-B and intrinsic subtypes (TNBC and HER2+) were identified as independent predictors of pCR-LN. pCR-LN (ypN0; hazard ratio 0.42; 95%, CI 0.23-0.75; p = 0.0028 for iDFS) was the strongest independent prognostic factor. Conclusions: In initially pN+ patients undergoing NAST, the conversion to ypN0 is of high prognostic value. Surgical axillary staging after NAST is still essential in these patients to offer tailored treatment.

Autoren

Gerber, Bernd
Schneeweiss, Andreas
Möbus, Volker
Golatta, Michael
Tesch, Hans
Krug, David
Hanusch, Claus Alexander
Denkert, Carsten Michael
Lübbe, Kristina
Heil, Jörg
Huober, Jens
Ataseven, Beyhan
Klare, Peter
Hahn, Markus
Untch, Michael
Kast, Karin
Jackisch, Christian
Thomalla, Jörg
Seither, Fenja
Blohmer, Jens-Uwe
Rhiem, Kerstin E. M.
Fasching, Peter Andreas
Nekljudova, Valentina
Loibl, Sibylle
Kühn, Thorsten

Einrichtung

UMR/Hochschulambulanz/Frauenklinik