Publikation: Zeitschriftenartikel

Planning benchmark study for stereotactic body radiation therapy of liver metastases

Grunddaten
Abstract
Autoren
Einrichtung

Grunddaten

Titel	Planning benchmark study for stereotactic body radiation therapy of liver metastases
Untertitel	results of the DEGRO/DGMP working group on stereotactic radiation therapy and radiosurgery : physics contribution
Erscheinungsjahr	2022
Seiten (von – bis)	214 – 227
Band	113
Heft-Nr.	1
Jahr	2022
Publikationsform	Elektronische Ressource
Publikationsart	Zeitschriftenartikel
Sprache	Englisch
DOI	10.1016/j.ijrobp.2022.01.008
Letzte Änderung	29.02.2024 04:52:03
Bearbeitungsstatus	durch UB Rostock abschließend validiert
Dauerhafte URL	http://purl.uni-rostock.de/fodb/pub/68923
Links zu Katalogen

Abstract

Purpose - Our purpose was to investigate whether liver stereotactic body radiation therapy treatment planning can be harmonized across different treatment planning systems, delivery techniques, and institutions by using a specific prescription method and to minimize the knowledge gap concerning intersystem and interuser differences. We provide best practice guidelines for all used techniques. - Methods and Materials - A multiparametric specification of target dose (gross target volume [GTV]D50%, GTVD0.1cc, GTVV90%, planning target volume [PTV]V70%) with a prescription dose of GTVD50% = 3 × 20 Gy and organ-at-risk (OAR) limits were distributed with computed tomography and structure sets from 3 patients with liver metastases. Thirty-five institutions provided 132 treatment plans using different irradiation techniques. These plans were first analyzed for target and OAR doses. Four different renormalization methods were performed (PTVDmin, PTVD98%, PTVD2%, PTVDmax). The resulting 660 treatments plans were evaluated regarding target doses to study the effect of dose renormalization to different prescription methods. A relative scoring system was used for comparisons. - Results - GTVD50% prescription can be performed in all systems. Treatment plan harmonization was overall successful, with standard deviations for Dmax, PTVD98%, GTVD98%, and PTVDmean of 1.6, 3.3, 1.9, and 1.5 Gy, respectively. Primary analysis showed 55 major deviations from clinical goals in 132 plans, whereas in only <20% of deviations GTV/PTV dose was traded for meeting OAR limits. GTVD50% prescription produced the smallest deviation from target planning objectives and between techniques, followed by the PTVDmax, PTVD98%, PTVD2%, and PTVDmin prescription. Deviations were significant for all combinations but for the PTVDmax prescription compared with GTVD50% and PTVD98%. Based on the various dose prescription methods, all systems significantly differed from each other, whereas GTVD50% and PTVD98% prescription showed the least difference between the systems. - Conclusions - This study showed the feasibility of harmonizing liver stereotactic body radiation therapy treatment plans across different treatment planning systems and delivery techniques when a sufficient set of clinical goals is given.

Autoren

Moustakis, Christos
Blanck, Oliver
Chan, Mark Ka Heng
Boda-Heggemann, Judit
Andratschke, Nicolaus
Duma, Marciana Nona
Albers, Dirk
Bäumer, Christian
Fehr, Roman
Körber, Stefan A.
Schmidhalter, Daniel
Alraun, Manfred
Baus, Wolfgang W.
Beckers, Eric
Dierl, Mathias
Droege, Stephan
Tazehmahalleh, Fatemeh Ebrahimi
Fleckenstein, Jens
Guckenberger, Matthias
Heinz, Christian
Henkenberens, Christoph
Hennig, Andreas
Köhn, Janett
Kornhuber, Christine Barbara
Krieger, Thomas Heinrich Richard
Loutfi-Krauss, Britta
Mayr, Manfred Mayr
Oechsner, Markus
Pfeiler, Tina
Pollul, Gerhard
Schöffler, Jürgen
Tümmler, Heiko
Ullm, Claudia
Walke, Mathias
Weigel, Rocco
Wertman, Martin
Wiehle, Rolf
Wiezorek, Tilo
Wilke, Lotte
Wolf, Ulrich
Eich, Hans Theodor
Schmitt, Daniela

Einrichtung

UMR/Hochschulambulanz/Strahlentherapie