Publikation: Teil einer Monographie/eines Konferenzbandes

Conceptional modeling and analysis of spatio-temporal processes in biomolecular systems

Grunddaten
Abstract
Autoren
Einrichtung

Grunddaten

Titel	Conceptional modeling and analysis of spatio-temporal processes in biomolecular systems
Veröffentlicht in	Conceptual modelling 2009 : proceedings of the Sixth Asia-Pacific Conference on Conceptual Modelling (APCCM 2009), Wellington, New Zealand, January 2009. - Sydney : Australian Computer Society
Erscheinungsjahr	2009
Seiten (von – bis)	39 – 48
Jahr	2009
Publikationsform	Druckschrift
Publikationsart	Teil einer Monographie/eines Konferenzbandes
Sprache	Englisch
Letzte Änderung	17.05.2019 16:32:07
Bearbeitungsstatus	durch UB Rostock abschließend validiert
Dauerhafte URL	http://purl.uni-rostock.de/fodb/pub/32479
Links zu Katalogen

Abstract

In life science, deeper understanding of biomolecular systems is acquired by computational modeling and analysis. For the modeling of several kinds of reaction networks, e.g. signaling pathways, information on intracellular space, like the locations and motions of molecules, has to be taken into account. In this paper, we introduce Labeled SpacePi, an extension of the pi-calculus, in order to model spatio-temporal processes in cells. The formalism is tailored to the available data and knowledge about biomolecular systems. For the analysis, we employ model checking techniques known from the field of safety-critical systems. To this end, we develop a translation of Labeled SpacePi models into hybrid automata. Two use cases - one considering the activation of a signaling pathway and the other one concerning active transport in cells - demonstrate our concept by making use of the established analysis tools HyTech and HySat.

Autoren

Schäfer, Andreas

John, Mathias

Einrichtung

IEF/Bereich Informatik