Publikation: Dissertationsschrift

Novel small molecules as GSK-3b inhibitors in human neural progenitor cells

Grunddaten
Links
Abstract
Autoren
Einrichtung

Grunddaten

Titel	Novel small molecules as GSK-3b inhibitors in human neural progenitor cells
Erscheinungsjahr	2010
Publikationsform	Elektronische Ressource
Publikationsart	Dissertationsschrift
Sprache	Englisch
Letzte Änderung	17.05.2019 09:25:19
Bearbeitungsstatus	durch UB Rostock abschließend validiert
Dauerhafte URL	http://purl.uni-rostock.de/fodb/pub/34990
Links zu Katalogen

Abstract

GSK-3ß as the key enzyme of Wnt/ß-catenin pathway is involved in various processes during the neuronal differentiation of stem and progenitor cells. Therefore small molecules are of great interest as they might provide new pharmacological tools to influence and study underlying mechanism. Thus, we developed a multi-level screening system to identify novel GSK-3ß inhibitors. The influence on Wnt/ß-catenin signaling was evaluated in human neural progenitor cells. New compounds raised the neuronal differentiation, whereat it was shown that the effect was due antagonistic action at GSK-3ß.

Autor

Schmöle, Anne-Caroline

Externe Links

Beschreibung	Link
Metadaten	http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2011-0014-9
Volltext (kostenfrei zugänglich ohne Registrierung)	http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2011-0014-9&pdf
Link zur Online-Ressource	http://nbn-resolving.de/urn:nbn:de:gbv:28-diss2011-0014-9

Einrichtung

MNF/Institut für Biowissenschaften (IfBI)