Publikation: Dissertationsschrift

Annexin A1 as a new functional linker between actin filaments and phagosomes during phagocytosis

Grunddaten
Abstract
Autoren
Einrichtung

Grunddaten

Titel	Annexin A1 as a new functional linker between actin filaments and phagosomes during phagocytosis
Erscheinungsjahr	2010
Publikationsform	Elektronische Ressource
Publikationsart	Dissertationsschrift
Sprache	Englisch
Letzte Änderung	13.03.2013 14:32:31
Bearbeitungsstatus	durch UB Rostock abschließend validiert
Dauerhafte URL	http://purl.uni-rostock.de/fodb/pub/34991
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Abstract

In the current study annexin A1 was identified as a factor, which binds to latex beads phagosomes (LBP) and facilitates F-actin-LBP interaction in vitro. In macrophages the association of endogenous annexin A1 with LBP membranes is strongly correlated with F-actin accumulation at the LBP. Furthermore, it showed that receptor signalling influenced annexin A1 recruitment on different LBP. Reduction of annexin A1 expression resulted in impaired phagocytosis and actin flashing. These data revealed that annexin A1 as an important component of opsonic phagocytosis.

Autor

Patel, Devang

Einrichtung

MNF/Institut für Biowissenschaften (IfBI)