Publikation: Zeitschriftenartikel

Coordination of crosstalk between MAPKPKC pathways: an exploratory study

Grunddaten
Abstract
Autoren
Einrichtung

Grunddaten

Titel	Coordination of crosstalk between MAPKPKC pathways: an exploratory study
Veröffentlicht in	IET systems biology. - Stevenage : IET
Erscheinungsjahr	2007
Seiten (von – bis)	33 – 40
Band	1
Heft-Nr.	1
Jahr	2007
Publikationsform	Druckschrift
Publikationsart	Zeitschriftenartikel
Sprache	Englisch
Letzte Änderung	20.05.2019 13:41:53
Bearbeitungsstatus	durch UB Rostock abschließend validiert
Dauerhafte URL	http://purl.uni-rostock.de/fodb/pub/36662
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Abstract

Networks of signaling pathways provide a robust mechanism for cells to respond to various biological stimuli. Cell adaptation through the viewpoint of an organising principle between two interconnected pathways mitogen-activated protein kinase (MAPK) and protein kinase C (PKC) is demonstrated. A multilevel system representation of the pathways is used to determine the pathway components contributing to the adaptive behaviour and coordination. The adaptation can be thought of as being manifested by a change in parameters of the coordinator. In silico experiments are conducted using MAPKPKC mathematical model in the literature, which is modularised using biological functionality. Through extensive, guided parametric in silico experiments, the PLA2 subsystem is shown to be a coordinator. Results show that varying parameters of the coordinator not only activate the network of pathways where otherwise the pathway activity is very low, but also reveal the ability of the system to activate itself in the absence of the input, indicating relevance of the principle of bounded autonomy.

Autoren

Sreenath, Sree N.
Soebiyanto, Radina P.
Mesarovic, M.D.
Wolkenhauer, Olaf

Einrichtung

IEF/Bereich Informatik