Publikation: Dissertationsschrift

The role of NF-kB and C/EBP factors during pathogen-mediated activation of bovine interleukin 8 and beta-defensin in mammary epithelial cells

Grunddaten
Abstract
Autoren
Einrichtung

Grunddaten

Titel	The role of NF-kB and C/EBP factors during pathogen-mediated activation of bovine interleukin 8 and beta-defensin in mammary epithelial cells
Erscheinungsjahr	2009
Publikationsform	Elektronische Ressource
Publikationsart	Dissertationsschrift
Sprache	Englisch
Letzte Änderung	19.03.2013 10:57:34
Bearbeitungsstatus	durch UB Rostock abschließend validiert
Dauerhafte URL	http://purl.uni-rostock.de/fodb/pub/39456
Links zu Katalogen

Abstract

Molecular mechanisms of pathogen-induced activation of the IL-8 and LAP genes were investigated in Mammary Epithelial Cells. Activity of the resting IL-8 promoter is inhibited by NF-kappaB p65, but activated quickly after pathogen contact by C/EBP factors. Conversely, NF-kappaB p65 drives LAP expression some time after pathogen induction, while C/EBP factors attenuate activity of this promoter. Hence, in the very same cell type NF-kappaB p65 and C/EBP factors antagonistically regulate both immune relevant genes before and after pathogen mediated stimulation.

Autor

Liu, Shuzhen

Einrichtung

MNF/Institut für Biowissenschaften (IfBI)