Publikation: Dissertationsschrift

The impact of tumor necrosis factor on osteogenic differentiation of human adipose tissue-derived stem cells in vitro

Grunddaten
Links
Abstract
Autoren
Einrichtung

Grunddaten

Titel	The impact of tumor necrosis factor on osteogenic differentiation of human adipose tissue-derived stem cells in vitro
Erscheinungsjahr	2012
Publikationsform	Elektronische Ressource
Publikationsart	Dissertationsschrift
Sprache	Englisch
Letzte Änderung	11.02.2014 02:12:42
Bearbeitungsstatus	durch UB Rostock abschließend validiert
Dauerhafte URL	http://purl.uni-rostock.de/fodb/pub/43887
Links zu Katalogen

Abstract

Chronic inflammatory diseases are characterized by elevated levels of tumor necrosis factor (TNF) and decreasing bone mineral density. TNF promotes differentiation of bone resorbing osteoclasts from their hematopoietic precursors. Its impact on differentiation of mesenchymal precursors of bone forming osteoblasts isolated from adipose (ASC) was largely unknown. I found that TNF did neither induce osteoblastic differentiation of ASC nor exhibited an impact on osteoblastic differentiation in vitro. Thus, TNF mediates osteolysis in vivo presumably mainly by its pro-osteoclastogenic effect.

Autor

Salamon, Achim

Externe Links

Beschreibung	Link
Metadaten	http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2014-0040-8
Volltext (kostenfrei zugänglich ohne Registrierung)	http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2014-0040-8&pdf
Link zur Online-Ressource	http://nbn-resolving.de/urn:nbn:de:gbv:28-diss2014-0040-8

Einrichtung

MNF/Institut für Biowissenschaften (IfBI)