Publikation: Dissertationsschrift

Compartmental modelling of the Wnt pathway

Grunddaten
Abstract
Autoren
Einrichtung

Grunddaten

Titel	Compartmental modelling of the Wnt pathway
Untertitel	elucidating the role of nucleo-cytoplasmic shuttling of -catenin and its antagonists
Erscheinungsjahr	2013
Publikationsform	Elektronische Ressource
Publikationsart	Dissertationsschrift
Sprache	Englisch
Letzte Änderung	28.03.2022 06:02:09
Bearbeitungsstatus	durch UB Rostock abschließend validiert
Dauerhafte URL	http://purl.uni-rostock.de/fodb/pub/44209
Links zu Katalogen

Abstract

The Wnt pathway plays a critical role in development and disease. The key player of the pathway is b-cat. In the nucleus, the complex formation of b-cat and TCF initiates target gene expression. Its activity is mainly regulated by retention and degradation by its antagonists APC, Axin and GSK3. Based on experimental findings, I develop and investigate compartmental models in order to analyse of the role of nucleo-cytoplasmic shuttling of these proteins in Wnt signalling. I show that the compartmental separation of b-cat and its antagonists yields an increase of the b-cat/TCF concentration.

Autor

Schmitz, Yvonne

Einrichtung

IEF/Bereich Informatik