Publikation: Dissertationsschrift

Role of HCN channels in regulation of synaptic plasticity at early postnatal medial perforant path

Grunddaten
Abstract
Autoren
Einrichtung

Grunddaten

Titel	Role of HCN channels in regulation of synaptic plasticity at early postnatal medial perforant path
Erscheinungsjahr	2013
Publikationsform	Elektronische Ressource
Publikationsart	Dissertationsschrift
Sprache	Englisch
Letzte Änderung	04.04.2014 02:12:34
Bearbeitungsstatus	durch UB Rostock abschließend validiert
Dauerhafte URL	http://purl.uni-rostock.de/fodb/pub/44558
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Abstract

HCN channel blocker ZD7288 depressed synaptic transmission at medial perforant path (MPP) synapses. Low-frequency stimulation (LFS) delivered to these fibers resulted in enhanced LTD after ZD7288 in P9-15 rats, but not in P30-60 rats. Hence, HCN channel activation during neuronal activity may compromise the propensity of LTD at these synapses. Results obtained with L-NAME iterated the effect of HCN channel inhibition on LTD, suggesting that retrograde signaling with NO might play a major role in the linkage between postsynaptic NMDAR activation and presynaptic HCN channel function.

Autor

Guli, Xiati

Einrichtung

UMR/Institut für Anatomie