Publikation: Dissertationsschrift

Gene mutations and losses of heterozygosity of TP53 and PTEN in colorectal cancer

Grunddaten
Abstract
Autoren
Einrichtung

Grunddaten

Titel	Gene mutations and losses of heterozygosity of TP53 and PTEN in colorectal cancer
Erscheinungsjahr	2014
Publikationsform	Elektronische Ressource
Publikationsart	Dissertationsschrift
Sprache	Englisch
Letzte Änderung	28.11.2014 02:13:35
Bearbeitungsstatus	durch UB Rostock abschließend validiert
Dauerhafte URL	http://purl.uni-rostock.de/fodb/pub/46403
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Abstract

This study was conducted to find out if the patterns of PTEN gene molecular aberration in colorectal carcinoma are consistent with the classic molecular features ascribed to a tumour suppressor gene. PTEN gene mutations and LOH were assayed in a series of 18 colorectal carcinomas. Three PTEN gene mutations were found in 1 tumour, complete loss of one allele(LOH)in 2 tumours and allelic imbalance (AI) in 6 tumours. LOH or AI did not target the 1 tumour with the PTEN gene mutations. The widely held belief of PTEN as a classical tumour suppressor gene is not supported by the findings from this study.

Autor

Salem, Tareq

Einrichtung

UMR/Institut für Pathologie