Publikation: Dissertationsschrift

The regenerative potential of the CD117+AT2R stimulated cell population in vitro and in vivo

Grunddaten
Abstract
Autoren
Einrichtung

Grunddaten

Titel	The regenerative potential of the CD117+AT2R stimulated cell population in vitro and in vivo
Erscheinungsjahr	2014
Publikationsform	Elektronische Ressource
Publikationsart	Dissertationsschrift
Sprache	Englisch
Letzte Änderung	28.08.2015 02:14:01
Bearbeitungsstatus	durch UB Rostock abschließend validiert
Dauerhafte URL	http://purl.uni-rostock.de/fodb/pub/49028
Links zu Katalogen

Abstract

Regarding innovative therapeutical approaches for cardiac regeneration, we thoroughly investigated CD117+ and CD117+AT2R stimulated murine bone marrow stem cells. Electrophysiological measurements and in vitro results indicated the differentiation into an endothelial-like phenotype excluding a previously discussed development into cardiomyocytes. Cell implantation into infarcted murine heart provoked a significant improvement of cardiac function. AT2R triggered effects were not significantly different and should be analyzed in interplay with its opposing receptor AT1.

Autor

Ludwig, Marion

Einrichtung

UMR/Klinik und Poliklinik für Chirurgie (CUK)