Publikation: Dissertationsschrift

Molecular, immunological and genetic studies on murine autoimmune pancreatitis

Grunddaten
Abstract
Autoren
Einrichtung

Grunddaten

Titel	Molecular, immunological and genetic studies on murine autoimmune pancreatitis
Erscheinungsjahr	2015
Publikationsform	Elektronische Ressource
Publikationsart	Dissertationsschrift
Sprache	Englisch
Letzte Änderung	19.12.2015 03:19:19
Bearbeitungsstatus	durch UB Rostock abschließend validiert
Dauerhafte URL	http://purl.uni-rostock.de/fodb/pub/49960
Links zu Katalogen

Abstract

To identify susceptible regions of the genome(quantitative trait loci; QTLs)controlling Autoimmune pancreatitis in a mouse model of the disease, we established an advanced intercross line originating from three inbred mouse strains: MRL/MpJ,BXD2,NZM and wild derived strain Cast. The fourth generation of outbred intercross mice was characterized phenotypically by scoring histopathological changes of the pancreas and genotyped (Illumina, USA).Five QTLs, regulating the severity of AIP, were identified, which mapped to chromosomes 2,4,5 and 6(with Logarithmic P values varied from 3.2 to 5.4).

Autor

Asghari, Farahnaz

Einrichtung

UMR/Zentrum für Innere Medizin (ZIM)