Publikation: Dissertationsschrift

Influence of polymer surface modification and specific growth factor stimulation on cellular adhesion at the implant/endothelium interface

Grunddaten
Link
Abstract
Autoren
Einrichtung

Grunddaten

Titel	Influence of polymer surface modification and specific growth factor stimulation on cellular adhesion at the implant/endothelium interface
Erscheinungsjahr	2014
Verlag	Universität Rostock
Verlagsort	Rostock
Publikationsform	Elektronische Ressource
Publikationsart	Dissertationsschrift
Sprache	Englisch
Letzte Änderung	28.03.2017 16:24:57
Bearbeitungsstatus	durch UB Rostock abschließend validiert
Dauerhafte URL	http://purl.uni-rostock.de/fodb/pub/52604
Links zu Katalogen

Abstract

The response of human endothelial cells (ECs) to poly(-caprolactone) (PCL) and eight different PCL modifications was examined in vitro. In CLSM, cell proliferation and viability testing, ECs responded best to plasma chemical activation of PCL. When ECs were additionally stimulated by VEGF, their maximum response was again seen on plasma activated PCL. Polymer precoating with matrix proteins was found to be beneficial for EC adhesion. A qPCR study of eNOS, IL-8, ICAM-1, PECAM-1 and VCAM-1 transcripts after VEGF stimulation of ECs on four modified and coated PCL surfaces was also performed.

Autor

Storm, Thilo

Externer Link

Beschreibung	Link
Link zur Online-Ressource (kostenfrei zugänglich ohne Registrierung)	http://rosdok.uni-rostock.de/resolve/urn/urn:nbn:de:gbv:28-diss2016-0085-0

Einrichtung

MNF/Institut für Biowissenschaften (IfBI)