Publikation: Dissertationsschrift

Wnt3a induces neuronal differentiation and crosstalk between Wnt/Ca2+-pathway and Wnt/b-catenin pathway

Grunddaten
Link
Abstract
Autoren
Einrichtung

Grunddaten

Titel	Wnt3a induces neuronal differentiation and crosstalk between Wnt/Ca2+-pathway and Wnt/b-catenin pathway
Erscheinungsjahr	2015
Verlag	Universität Rostock
Verlagsort	Rostock
Publikationsform	Elektronische Ressource
Publikationsart	Dissertationsschrift
Sprache	Englisch
Letzte Änderung	15.05.2019 20:04:58
Bearbeitungsstatus	durch UB Rostock abschließend validiert
Dauerhafte URL	http://purl.uni-rostock.de/fodb/pub/54652
Links zu Katalogen

Abstract

HumanNPCs (hNPCs) are the suitable cell source in translation medicine for neurodegenerative disease. In the present study, effects of Wnt3a on the differentiation of hNPC were studied. The results showed that Wnt3a induces canonical and non canonical Wnt pathways. Furthermore, Wnt3a increases Ca2+ target genes CaMKII and Pyk2 in the differentiating VM cells. The results demonstrated that Pyk2 decreases GSK3b activity and stabilizes b-catenin, suggesting there is an intercross between Wnt/b-catenin and Wnt/Ca2+-pathway via Pyk2.

Autor

Talabattula, Venkata Ajay Narendra

Externer Link

Beschreibung	Link
Link zur Online-Ressource (kostenfrei zugänglich ohne Registrierung)	http://rosdok.uni-rostock.de/resolve/urn/urn:nbn:de:gbv:28-diss2017-0048-9

Einrichtung

UMR/Zentrum für Innere Medizin (ZIM)