Publikation: Dissertationsschrift

Adhesive mechanisms of histone-induced neutrophil-endothelium interactions in the muscle microcirculation

Grunddaten
Link
Abstract
Autoren
Einrichtung

Grunddaten

Titel	Adhesive mechanisms of histone-induced neutrophil-endothelium interactions in the muscle microcirculation
Erscheinungsjahr	2016
Verlag	Universität Rostock
Verlagsort	Rostock
Publikationsform	Elektronische Ressource
Publikationsart	Dissertationsschrift
Sprache	Englisch
Letzte Änderung	10.01.2018 10:30:36
Bearbeitungsstatus	durch UB Rostock abschließend validiert
Dauerhafte URL	http://purl.uni-rostock.de/fodb/pub/55362
Links zu Katalogen

Abstract

Intravital microscopy of the mouse cremaster microcirculation was used to examine the role of specific adhesion molecules in histone-dependent leukocyte recruitment. Histones type 3 were given locally to the cremaster muscle sack and specific adhesion molecules were blocked by systemic administration of monoclonal antibodies. Extracellular histones 3 induced leukocyte recruitment in a dose-dependent manner. Histone-induced neutrophil rolling is predominately mediated by P-selectin/PSGL-1 interactions, whereas histone-induced leukocyte adhesion is inter alia mediated by Mac-1 and LFA-1.

Autor

Pügge, Johanna

Externer Link

Beschreibung	Link
Link zur Online-Ressource (kostenfrei zugänglich ohne Registrierung)	http://rosdok.uni-rostock.de/resolve/urn/urn:nbn:de:gbv:28-diss2017-0168-6

Einrichtung

UMR/Rudolf-Zenker-Institut für Experimentelle Chirurgie