Publikation: Dissertationsschrift

Differentiation and survival of human neural progenitor cells in 3D scaffolds of self-assembling peptide hydrogels

Grunddaten
Abstract
Autoren
Einrichtung

Grunddaten

Titel	Differentiation and survival of human neural progenitor cells in 3D scaffolds of self-assembling peptide hydrogels
Erscheinungsjahr	2013
Verlag	Universität Rostock
Verlagsort	Rostock
Publikationsform	Elektronische Ressource
Publikationsart	Dissertationsschrift
Sprache	Englisch
DOI	10.18453/rosdok_id00002503
Letzte Änderung	01.08.2019 06:04:55
Bearbeitungsstatus	durch UB Rostock abschließend validiert
Dauerhafte URL	http://purl.uni-rostock.de/fodb/pub/61524
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Abstract

In this project we used a human neural progenitor cell line (hNPCs), whereat the cells were embedded in the synthetic self-assembling peptide hydrogel and modified formulations. Different protocols of culture conditions (2D versus 3D) were compared to analyze the neuronal differentiation and survival of the cells. The hydrogels enhance the neuronal differentiation of the hNPCs of about 2.3 fold, with an additional increase of about 2,5 fold more for the modified Scaffolds. Additionally the hNPCs were protected from apoptosis and accordingly survived longer when encapsulated in 3D scaffolds.

Autor

Liedmann, Andrea

Einrichtung

UMR/KN/Sektion für Translationale Neurogeneration "Albrecht Kossel"