Publikation: Dissertationsschrift

Effect of cannabidiol on disease-associated functions of human vascular smooth muscle cells

Grunddaten
Abstract
Autoren
Einrichtung

Grunddaten

Titel	Effect of cannabidiol on disease-associated functions of human vascular smooth muscle cells
Untertitel	role of the anti-oxidative enzyme heme oxygenase-1
Erscheinungsjahr	2018
Verlagsort	Rostock
Seitenzahl	122
Publikationsform	Druckschrift
Publikationsart	Dissertationsschrift
Sprache	Englisch
Letzte Änderung	28.08.2019 06:04:16
Bearbeitungsstatus	durch UB Rostock abschließend validiert
Dauerhafte URL	http://purl.uni-rostock.de/fodb/pub/61638
Links zu Katalogen

Abstract

Excessive proliferation and migration of VSMC are closely linked to cardiovascular diseases and cancer. The enzyme HO-1 was shown to be involved in anti-proliferative/anti-migratory effects in VSMC. This thesis investigates the effect of CBD on VSMC and HO-1. HO-1 was significantly increased by CBD in an ROS-depentent manner. In addition, inhibition of proliferation and migration of VSMC were observed and not attenuated by inhibition/knockdown of HO-1. This work provides evidence of a CBD-mediated induction of HO-1 in VSMC and potential protective effects via an HO-1-independent mechanism.

Autor

Schwartz, Margit

Einrichtung

UMR/Zentrum für Innere Medizin (ZIM)