Publikation: Dissertationsschrift

Effects of group I metabotropic glutamate receptors on internalization of AMPA receptors in NPC1 mutant mouse

Grunddaten
Abstract
Autoren
Einrichtung

Grunddaten

Titel	Effects of group I metabotropic glutamate receptors on internalization of AMPA receptors in NPC1 mutant mouse
Erscheinungsjahr	2018
Verlagsort	Rostock
Seitenzahl	71, vii
Publikationsform	Druckschrift
Publikationsart	Dissertationsschrift
Sprache	Englisch
Letzte Änderung	03.01.2020 06:04:36
Bearbeitungsstatus	durch UB Rostock abschließend validiert
Dauerhafte URL	http://purl.uni-rostock.de/fodb/pub/62091
Links zu Katalogen

Abstract

NPC1 disease is characterized by neurodegeneration caused by cholesterol accumulation. In this study, defective internalization of GluR2-containing AMPA receptors in NPC1-/- neurons is found to be related to dysfunctional mGluR1/5. Stimulation of mGluR1/5 increases the internalization and downregulates over-influx of calcium. Moreover, p-GluR2 and PKC are proposed to be involved in this regulation. Our data imply that abnormal internalization of AMPA receptors is a critical mechanism for neuronal dysfunction and correction of mGluR1/5 is a potential therapeutic strategy for NPC1 disease.

Autor

Feng, Xiao

Einrichtung

UMR/KN/Sektion für Translationale Neurogeneration "Albrecht Kossel"