Publikation: Dissertationsschrift

Autophagy in cancer-associated fibroblasts and the p38 MAPK signaling pathway regulate the anticancerous efficacy of -cyano-4-hydroxycinnamate in pancreatic cancer

Grunddaten
Abstract
Autoren
Einrichtung

Grunddaten

Titel	Autophagy in cancer-associated fibroblasts and the p38 MAPK signaling pathway regulate the anticancerous efficacy of -cyano-4-hydroxycinnamate in pancreatic cancer
Erscheinungsjahr	2019
Verlagsort	Rostock
Publikationsform	Druckschrift
Publikationsart	Dissertationsschrift
Sprache	Englisch
Letzte Änderung	22.01.2020 11:30:17
Bearbeitungsstatus	durch UB Rostock abschließend validiert
Dauerhafte URL	http://purl.uni-rostock.de/fodb/pub/62818
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Abstract

In this study, we observed that -cyano-4-hydroxycinnamate induced apoptosis via stimulating p38 mitogen-activated protein kinase signaling pathway. Moreover, -cyano-4-hydroxycinnamate enhanced chemosensitivity to metformin in vitro. Interestingly, inhibition of autophagy in cancer-associated fibroblasts improved the anti-proliferative efficacy of these two treatments and gemcitabine, the first-line chemotherapy for pancreatic cancer. These data suggested that blocking autophagy in cancer-associated fibroblasts supports the anticancerous efficacy of chemotherapeutics.

Autor

Zhang, Xianbin

Einrichtung

UMR/Rudolf-Zenker-Institut für Experimentelle Chirurgie