Publikation: Dissertationsschrift

Antiarrhythmic effect of human bone marrow-dereived CD271+ mesenchymal stem cells tested in vivo using a new infarction-re-infarction mouse model

Grunddaten
Abstract
Autoren
Einrichtung

Grunddaten

Titel	Antiarrhythmic effect of human bone marrow-dereived CD271+ mesenchymal stem cells tested in vivo using a new infarction-re-infarction mouse model
Erscheinungsjahr	2021
Verlagsort	Rostock
Publikationsform	Druckschrift
Publikationsart	Dissertationsschrift
Sprache	Englisch
Letzte Änderung	18.03.2021 06:04:46
Bearbeitungsstatus	durch UB Rostock abschließend validiert
Dauerhafte URL	http://purl.uni-rostock.de/fodb/pub/65371
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Abstract

This experiment showed the safety and antiarrhythmic effect of human bone marrow-derived CD271+ MSC. This was performed in immune deficient mice (Rag2-/-c-/--mice) with electrocardiogram monitoring through Implantation of telemtry system. The induction of ventricular arrhythmias has been achieved via a permanent re-infarction through left anterior descending artery (LAD) ligation one week after a 30-minute ischemia-reperfusion. The time between 2 infarctions gave the stem cells the required period to entgraft themselves after their intramyocardial injection with the first infarction.

Autor

Sadraddin, Haval Lutfalla

Einrichtung

UMR/Zentrum für Innere Medizin (ZIM)