Publikation: Dissertationsschrift

Stressors modulating granulosa cell functionality, ovulation and oocyte competence in bovines

Grunddaten
Abstract
Autoren
Einrichtung

Grunddaten

Titel	Stressors modulating granulosa cell functionality, ovulation and oocyte competence in bovines
Erscheinungsjahr	2020
Verlagsort	Rostock
Seitenzahl	165, iii
Publikationsform	Druckschrift
Publikationsart	Dissertationsschrift
Sprache	Englisch
Letzte Änderung	31.03.2021 06:02:49
Bearbeitungsstatus	durch UB Rostock abschließend validiert
Dauerhafte URL	http://purl.uni-rostock.de/fodb/pub/65502
Links zu Katalogen

Abstract

Ovarian follicles are exposed to stressors such as higher levels of non-esterified free fatty acids (NEFAs) or hypoxia. High follicular levels of NEFA severely affect granulosa cells (GCs) by targeting key genes of estradiol biosynthesis. Cultured GCs exposed to hypoxia showed specific regulation of genes that initiate luteinization. These effects were partly mediated by hypoxia inducible factor1 (HIF1). Thus, ovarian follicles are susceptible to elevated NEFA levels, but cope up with severe hypoxia prevailing during late folliculogenesis through specific transcription factors such as HIF1.

Autor

Sharma, Arpna

Einrichtung

Mathematisch-Naturwissenschaftliche Fakultät (MNF)