Publikation: Dissertationsschrift

Immunoglobulin G mediates chemoresistance to oxaliplatin in colon cancer cells by inhibiting the ERK signal transduction pathway

Grunddaten
Abstract
Autoren
Einrichtung

Grunddaten

Titel	Immunoglobulin G mediates chemoresistance to oxaliplatin in colon cancer cells by inhibiting the ERK signal transduction pathway
Erscheinungsjahr	2019
Verlagsort	Rostock
Seitenzahl	75
Publikationsform	Druckschrift
Publikationsart	Dissertationsschrift
Sprache	Englisch
Letzte Änderung	09.06.2021 06:02:18
Bearbeitungsstatus	durch UB Rostock abschließend validiert
Dauerhafte URL	http://purl.uni-rostock.de/fodb/pub/65874
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Abstract

The aim of this study was to investigate the effect of therapeutically used immunoglobulin G (IgG) on colon cancer in the presence of oxaliplatin. We observed that IgG failed to significantly influence tumor cell viability and tumor growth; however, it significantly inhibited the cytotoxic activity of oxaliplatin in vitro. In addition, we observed that oxaliplatin-induced the activation of ERK; however, IgG inhibits ERK activity. This implies that the application of therapeutical IgG to treating patients, which are receiving oxaliplatin, might have harmful side effects.

Autor

Shang, Yuru

Einrichtung

UMR/Klinik und Poliklinik für Chirurgie (CUK)