Publikation: Zeitschriftenartikel

Therapeutic drug monitoring of sertraline in children and adolescents

Grunddaten
Abstract
Autoren
Einrichtung

Grunddaten

Titel	Therapeutic drug monitoring of sertraline in children and adolescents
Untertitel	a naturalistic study with insights into the clinical response and treatment of obsessive-compulsive disorder
Erscheinungsjahr	2022
Seiten (von – bis)	1 – 11
Band	115
Jahr	2022
Publikationsform	Elektronische Ressource
Publikationsart	Zeitschriftenartikel
Sprache	Englisch
DOI	10.1016/j.comppsych.2022.152301
Letzte Änderung	11.01.2023 06:02:13
Bearbeitungsstatus	durch UB Rostock abschließend validiert
Dauerhafte URL	http://purl.uni-rostock.de/fodb/pub/68911
Links zu Katalogen

Abstract

BACKGROUND: Sertraline is a selective serotonin reuptake inhibitor with specific indications in child and adolescent psychiatry. Notwithstanding its frequent use and clinical benefits, the relationship between pharmacokinetics, pharmacodynamics, efficacy, and tolerability of sertraline across indications, particularly in non-adult patients, is not fully understood. - METHOD: This naturalistic therapeutic drug monitoring (TDM) study was conducted in a transdiagnostic sample of children and adolescents treated with sertraline (n = 78; mean age, 14.22 ± 2.39; range, 7-18 years) within the prospective multicenter "TDM-VIGIL" project. Associations between dose, serum concentration, and medication-specific therapeutic and side effects based on the Clinical Global Impression scale were examined. Tolerability was measured qualitatively with the 56-item Pediatric Adverse Event Rating Scale. - RESULTS: A strong linear positive dose-serum concentration relationship (with dose explaining 45% of the variance in concentration) and significant effects of weight and co-medication were found. Neither dose nor serum concentration were associated with side effects. An overall mild-to-moderate tolerability profile of sertraline was observed. In contrast with the transdiagnostic analysis that did not indicate an effect of concentration, when split into depression (MDD) and obsessive-compulsive disorder (OCD) diagnoses, the probability of clinical improvement significantly increased as both dose and concentration increased for OCD, but not for MDD. - CONCLUSIONS: This TDM-flexible-dose study revealed a significant diagnosis-specific effect between sertraline serum concentration and clinical efficacy for pediatric OCD. While TDM already guides clinical decision-making regarding compliance, dose calibration, and drug-drug interactions, combining TDM with other methods, such as pharmacogenetics, may facilitate a personalized medicine approach in psychiatry.

Autoren

Tini, Elvira
Smigielski, Lukasz
Romanos, Marcel
Wewetzer, Christoph
Karwautz, Andreas
Reitzle, Karl
Correll, Christoph U.
Plener, Paul L.
Malzahn, Uwe
Heuschmann, Peter
Unterecker, Stefan
Scherf-Clavel, Maike
Rock, Hans
Antony, Gisela
Briegel, Wolfgang
Fleischhaker, Christian
Banaschewski, Tobias
Hellenschmidt, Tobias
Imgart, Hartmut
Kaess, Michael
Kölch, Michael
Renner, Tobias
Reuter-Dang, Su-Yin
Rexroth, Christian
Schulte-Körne, Gerd
Theisen, Frank
Fekete, Stefanie
Taurines, Regina
Gerlach, Manfred
Egberts, Karin M.
Walitza, Susanne

Einrichtung

UMR/Klinik und Poliklinik für Psychiatrie, Neurologie, Psychosomatik und Psychotherapie im Kindes- und Jugendalter (KJPP)