Publikation: Dissertationsschrift

Assessing the impact of sodium butyrate and a light-activated proton pump on energy metabolism and lifespan of Drosophila melanogaster and Caenorhabditis elegans

Grunddaten
Abstract
Autoren
Einrichtung

Grunddaten

Titel	Assessing the impact of sodium butyrate and a light-activated proton pump on energy metabolism and lifespan of Drosophila melanogaster and Caenorhabditis elegans
Erscheinungsjahr	2023
Verlag	Universität Rostock
Verlagsort	Rostock
Publikationsform	Druckschrift
Publikationsart	Dissertationsschrift
Sprache	Englisch
Letzte Änderung	08.05.2024 06:02:04
Bearbeitungsstatus	durch UB Rostock abschließend validiert
Dauerhafte URL	http://purl.uni-rostock.de/fodb/pub/71770
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Abstract

In this thesis, the impact of sodium butyrate (SB) on mitochondrial and metabolic function and lifespan was investigated. SB treatment showed a rapid and transient increase in oxygen consumption in fly heads. Mass spectrometry analysis revealed incorporation of labeled SB into mitochondrial pathway metabolites. An SB-independent way for mitochondrial activation was assessed in this work. The mitochondrial membrane potential of C. elegans was increased, using a light-activated proton pump, resulting in an extended median lifespan, even if the intervention took part in mid- or late-staged worms.

Autor

Müller-Eigner, Annika

Einrichtung

MNF/Institut für Biowissenschaften (IfBI)