Publikation: Dissertationsschrift

Assessing the impact of sodium butyrate and a light-activated proton pump on energy metabolism and lifespan of Drosophila melanogaster and Caenorhabditis elegans

Grunddaten
Abstract
Autoren
Einrichtung

Grunddaten

Titel	Assessing the impact of sodium butyrate and a light-activated proton pump on energy metabolism and lifespan of Drosophila melanogaster and Caenorhabditis elegans
Erscheinungsjahr	2023
Verlag	Universität Rostock
Verlagsort	Rostock
Publikationsform	Elektronische Ressource
Publikationsart	Dissertationsschrift
Sprache	Englisch
DOI	10.18453/rosdok_id00004576
Letzte Änderung	08.05.2024 06:02:04
Bearbeitungsstatus	durch UB Rostock abschließend validiert
Dauerhafte URL	http://purl.uni-rostock.de/fodb/pub/71771
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Abstract

In this thesis, the impact of sodium butyrate (SB) on mitochondrial and metabolic function and lifespan was investigated. SB treatment showed a rapid and transient increase in oxygen consumption in fly heads. Mass spectrometry analysis revealed incorporation of labeled SB into mitochondrial pathway metabolites. An SB-independent way for mitochondrial activation was assessed in this work. The mitochondrial membrane potential of C. elegans was increased, using a light-activated proton pump, resulting in an extended median lifespan, even if the intervention took part in mid- or late-staged worms.

Autor

Müller-Eigner, Annika

Einrichtung

MNF/Institut für Biowissenschaften (IfBI)