Publikation: Dissertationsschrift

Development of a focused chemical library

Grunddaten
Links
Abstract
Autoren

Grunddaten

Titel	Development of a focused chemical library
Untertitel	synthesis of novel bioactive hymenialdisine derivatives
Erscheinungsjahr	2008
Publikationsform	Elektronische Ressource
Publikationsart	Dissertationsschrift
Sprache	Englisch
Letzte Änderung	19.03.2013 10:47:13
Bearbeitungsstatus	durch UB Rostock abschließend validiert
Dauerhafte URL	http://purl.uni-rostock.de/fodb/pub/30933
Links zu Katalogen

Abstract

This dissertation deals with the synthesis of novel bioactive derivatives of the natural occurring hymenialdisine. As a part of this project, a solvent-free, efficient, and easy to handle diversification strategy for annulated hymenialdisine-type bisindoles was developed. A C-C bond-formation reaction on activated silica under mild reaction conditions starting from aziridines, epoxides or hydroxyl compounds is the key technology. The versatility of different aziridines as key building blocks was demonstrated with H-, O-, and N-nucleophiles in a diversity oriented synthesis to build up a focused chemical library. Furthermore, novel transition metal mediated introduction and transformation of functional-groups for potential application in the synthesis of novel drug candidates were developed.

Autor

Kaiser, Hanns Martin

Externe Links

Beschreibung	Link
Link zur Online-Ressource	http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2008-0124-1
Link zur Online-Ressource	http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2008-0124-1&pdf
Link zur Online-Ressource	http://nbn-resolving.de/urn:nbn:de:gbv:28-diss2008-0124-1