Publikation: Dissertationsschrift

A systems biology approach to dynamic modelling of the AMP-activated kinase pathway

Grunddaten
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Abstract
Autoren
Einrichtung

Grunddaten

Titel	A systems biology approach to dynamic modelling of the AMP-activated kinase pathway
Erscheinungsjahr	2011
Publikationsform	Elektronische Ressource
Publikationsart	Dissertationsschrift
Sprache	Englisch
Letzte Änderung	19.03.2013 11:00:33
Bearbeitungsstatus	durch UB Rostock abschließend validiert
Dauerhafte URL	http://purl.uni-rostock.de/fodb/pub/34326
Links zu Katalogen

Abstract

A systems biology approach is used to investigate a key regulator of energy sensing, the AMPK/ Snf1 pathway. Therefore, a stimulus is derived considering transmembrane glucose transport. Fluorescent microscopy data of Mig1, a Snf1 pathway component, were processed through a mathematical approach. The data were compared to simulations of alternative network structures suggested to underlie the Snf1 pathway. Certain structures could be excluded. Besides, applying quantitative measures showed that the design of a MAPK pathway is favourable for the transmission of fast signals with short duration.

Autor

Frey, Simone

Externe Links

Beschreibung	Link
Metadaten	http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2011-0135-1
Volltext (kostenfrei zugänglich ohne Registrierung)	http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2011-0135-1&pdf
Link zur Online-Ressource	http://nbn-resolving.de/urn:nbn:de:gbv:28-diss2011-0135-1

Einrichtung

Fakultät für Informatik und Elektrotechnik (IEF)