Publikation: Dissertationsschrift

Exploring the spatio-temporal dynamics of lipid rafts and their role in signal transduction

Grunddaten
Link
Abstract
Autoren
Einrichtung

Grunddaten

Titel	Exploring the spatio-temporal dynamics of lipid rafts and their role in signal transduction
Untertitel	a modeling and simulation approach
Erscheinungsjahr	2015
Verlag	Universität Rostock
Verlagsort	Rostock
Publikationsform	Elektronische Ressource
Publikationsart	Dissertationsschrift
Sprache	Englisch
Letzte Änderung	28.03.2017 16:24:54
Bearbeitungsstatus	durch UB Rostock abschließend validiert
Dauerhafte URL	http://purl.uni-rostock.de/fodb/pub/52599
Links zu Katalogen

Abstract

The aim of this thesis is to elucidate the biological as well as methodological implications that arise from modeling the spatio-temporal dynamics of lipid rafts. Therefore the effect of raft-dependent receptors dynamics on both, individual signaling events as well as the canonical Wnt signaling pathway, is thoroughly analyzed. To explore the effect of lipid rafts on individual signaling events, a Cellular-Automata based membrane model is developed. The specific involvement of lipid rafts in Wnt/b-catenin signaling is explored by means of an integrated in silico and in vitro approach.

Autor

Haack, Fiete

Externer Link

Beschreibung	Link
Link zur Online-Ressource (kostenfrei zugänglich ohne Registrierung)	http://rosdok.uni-rostock.de/resolve/urn/urn:nbn:de:gbv:28-diss2016-0080-1

Einrichtung

IEF/Bereich Informatik