Publikation: Dissertationsschrift

Modeling perspective on translatability of deep brain stimulation mechanism for treating Parkinsonian motor symptoms in rodent and human

Grunddaten
Abstract
Autoren
Einrichtung

Grunddaten

Titel	Modeling perspective on translatability of deep brain stimulation mechanism for treating Parkinsonian motor symptoms in rodent and human
Erscheinungsjahr	2021
Verlagsort	Rostock
Seitenzahl	97, XLIX
Publikationsform	Druckschrift
Publikationsart	Dissertationsschrift
Sprache	Englisch
Letzte Änderung	28.04.2022 06:01:46
Bearbeitungsstatus	durch UB Rostock abschließend validiert
Dauerhafte URL	http://purl.uni-rostock.de/fodb/pub/68012
Links zu Katalogen

Abstract

Deep brain stimulation is an established treatment for Parkinson's disease (PD). However, to advance its effectiveness, researchers need to gain a better understanding of the action mechanism by means of in vivo and in silico studies. This thesis presents neural activation patterns theoretically beneficial for motor improvement in PD and analyzes their theoretical reproducibility in a rat brain. Besides, it elucidates biophysical and computational problems to be addressed in order to optimize animal studies and avoid misconceptions when transferring experimental findings to clinical trials.

Autor

Butenko, Konstantin

Einrichtung

Fakultät für Informatik und Elektrotechnik (IEF)